Oncology
Matsubase ENT & Internal Medicine Clinic
松橋耳鼻咽喉科・内科クリニック
Uki, Kumamoto
Treatments offered
- Hyperthermia
- Hyperbaric oxygen therapy
- Autologous cancer vaccine and Maruyama vaccine
- High-dose intravenous vitamin C
Oncology
Kumamoto Immunity Integrative Medicine Clinic
くまもと免疫統合医療クリニック
Koshi, Kumamoto
Kumamoto integrative oncology clinic combining low-dose checkpoint inhibitors, 8 MHz Thermotron hyperthermia, ICG photoimmunotherapy, hydrogen and autologous cancer vaccine; foreign patients welcome.
Treatments at Kumamoto Immunity Integrative Medicine Clinic
What each treatment is and how it is given. Whether it suits you is decided by the clinic’s physician after reviewing your records.
| Treatment | What it is | Type | Learn more |
|---|---|---|---|
| Immune checkpoint inhibitors | Nivolumab, ipilimumab or pembrolizumab infusions combined with immune-supporting therapies. | Chemotherapy & standard oncology | Ask your coordinator |
| Hyperthermia (Thermotron RF-8) | 8 MHz radiofrequency heating of the tumor to 42–44°C to damage cancer cells and activate immunity. | Hyperthermia | How it works → |
| ICG photoimmunotherapy | ICG-liposome infusion followed by near-infrared laser to tumors and circulating tumor cells. | NK, NKT & T-cell therapies | Related treatment → |
| Autologous cancer vaccine | Three intradermal injections over six weeks made from the patient's own tumor tissue. | Dendritic-cell & cancer vaccines | Related treatment → |
| Hydrogen inhalation and high-dose vitamin C | Antioxidant supportive therapies used alongside the main protocol. | Vitamin C, hydrogen & integrative care | How it works → |
Many treatments listed here are self-pay (not covered by Japanese public insurance) and some are not approved as standard treatment in Japan. Regenerative and cell therapies are provided under registered plans based on the Act on the Safety of Regenerative Medicine.
Costs depend on your case and differ for international patients. Your coordinator explains the clinic's fees, interpreter and coordination costs before you decide.
About the clinic
Kumamoto Immunity Integrative Medicine Clinic, led by surgical oncologist Dr. Junji Akagi, builds treatment around restoring anti-tumor immunity. Its protocols combine checkpoint inhibitors (nivolumab, ipilimumab, pembrolizumab) with Thermotron RF-8 hyperthermia, hydrogen inhalation, ICG-liposome photoimmunotherapy, chemotherapy and the autologous cancer vaccine, monitored with seven immune parameters including exhausted T cells. Patient accommodation is available nearby, and international patients are quoted separate prices.
- Integrative oncology
- Checkpoint inhibitors
- Hyperthermia
- Immune monitoring
Doctors
Junji Akagi 赤木 純児
Director
Surgical oncologist who developed the clinic's integrated protocol combining checkpoint inhibitors, hyperthermia and hydrogen with standard care, with a focus on PD-1-related immune exhaustion.
International patients
What the clinic publishes
Accepts international patients. International pricing differs from domestic; accommodation for patients available.
Languages: English, Chinese
What JapanMedAssist adds
- Records collection and Japanese translation
- Physician pre-review of your case
- Appointment scheduling
- Medical interpreter at every visit
- Visa and travel letter guidance
Access and hours
- Address
- Anbe Kumamoto Ichibangai, 2249-2 Takesako, Koshi, Kumamoto 861-1114 熊本県合志市竹迫2249-2 アンビー熊本一番街
- Hours
- 9:00–18:00 (lunch 12:00–13:30).
- Official website
- kc-iimc.jp
Ask us about this clinic
Send us your diagnosis and treatment history. A case coordinator will check whether this clinic fits your case, request a medical review, and explain costs and next steps before you travel.
Independent information. JapanMedAssist is not affiliated with Kumamoto Immunity Integrative Medicine Clinic unless stated.
How we arrange your visit
- 1
Send your records
Share your diagnosis, reports and imaging through our secure form. We translate them into Japanese.
- 2
Clinic match and physician review
We check which clinics fit your case and ask the clinic’s physician to review it before you travel.
- 3
Visit with an interpreter
We schedule appointments, arrange a medical interpreter and explain all costs before you decide.
Frequently asked questions
Does Kumamoto Immunity Integrative Medicine Clinic accept international patients?
Yes. International pricing differs from domestic; accommodation for patients available. JapanMedAssist can coordinate records translation, interpretation and scheduling.
How do I book Kumamoto Immunity Integrative Medicine Clinic from abroad?
Send your diagnosis and recent medical records through our consultation form, WhatsApp or Messenger. A coordinator checks whether this clinic fits your case, arranges a medical review, and explains costs and next steps before you travel.
How much does treatment at Kumamoto Immunity Integrative Medicine Clinic cost?
Costs depend on your case and differ for international patients. Your coordinator explains the clinic's fees, interpreter and coordination costs before you decide. Many treatments are self-pay and not covered by Japanese public insurance.
Which documents do I need?
Usually a referral letter or summary from your current doctor, recent pathology and imaging reports, and a list of treatments so far. We help you collect and translate them.
Where is Kumamoto Immunity Integrative Medicine Clinic?
Anbe Kumamoto Ichibangai, 2249-2 Takesako, Koshi, Kumamoto 861-1114.
Clinics offering similar treatments
Oncology
Benibana Internal Medicine Clinic
べにばな内科クリニック
Yamagata City, Yamagata
Treatments offered
- Microwave hyperthermia
- Cancer immune-cell therapy
- Autologous cancer vaccine
- CTC (circulating tumor cell) test
Oncology
Funato Clinic
船戸クリニック
Yoro-cho, Yoro-gun, Gifu
Treatments offered
- High-dose intravenous vitamin C
- Lymphocyte infusion therapy
- Low-dose nivolumab (Opdivo)
- Mild hyperthermia
- +1
Sources
Summarized from the clinic’s public website on 2026-09-28. Report an error